Paget's disease is a form of carcinoma associated with changes in the nipple.

Paget's disease is a form of carcinoma associated with changes in the nipple.

• A. Areola
• B. Milk ducts
• C. Skin
• D. Nipple

Answer: (D)

Paget disease of the breast is a carcinoma that involves the nipple-areolar complex, classically presenting with eczema-like changes of the nipple such as redness, itching, and scaling. The underlying malignancy often arises in the milk ducts, but the clinical changes are seen on the nipple itself. Because the question focuses on where these nipple-associated changes occur, the best answer is the nipple. The areola is part of the same complex and can be involved, but the defining, visible changes occur on the nipple. Milk ducts refer to the origin of the cancer, not the site of the nipple-specific changes, and “skin” is too broad a descriptor for this presentation.

Paget disease of the breast is a carcinoma that involves the nipple-areolar complex, classically presenting with eczema-like changes of the nipple such as redness, itching, and scaling. The underlying malignancy often arises in the milk ducts, but the clinical changes are seen on the nipple itself. Because the question focuses on where these nipple-associated changes occur, the best answer is the nipple. The areola is part of the same complex and can be involved, but the defining, visible changes occur on the nipple. Milk ducts refer to the origin of the cancer, not the site of the nipple-specific changes, and “skin” is too broad a descriptor for this presentation.